Cd8 enhancer E8I and Runx factors regulate CD8 expression in activated CD8+ T cells

Interferon- and interleukin-4 reciprocally regulate CD8 expression in CD8 T cells

The CD8 co-receptor can modulate CD8 T cell function through its contributions to T cell receptor (TCR) binding and signaling. Here we show that IFNand IL-4 exert opposing effects on the expression of CD8 mRNA and surface CD8 protein during CD8 T cell activation. IL-4 caused down-regulation of surface CD8 on ovalbumin (OVA)257–264-specific TCR-transgenic OT-I CD8 T cells activated with OVA257–2...

Activated Primary and Memory CD8 T Cells

CD8+ T Lymphocyte Subsets in Bladder Tumor Draining Lymph Nodes

Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. Objective: To investigate the percentages of CD8+ lymphocytes and their subsets in...

Numerical status of CD4+CD25+FoxP3+ and CD8+CD28- regulatory T cells in multiple sclerosis

Objective(s): Regulatory T cells, including CD4+CD25+Fox3+ and CD8+CD28- cells play an important role in regulating the balance between immunity and tolerance. Since multiple sclerosis is an inflammatory autoimmune disease, regulatory T cells are considered to be involved in its pathogenesis. In this study, we investigated the circulatory numbers of the two mentioned types of regulatory T cells...

CD8+CXCR5+ T Cells Regulate Pathology in the Genital Tract

We have identified a CD8⁺CXCR5⁺ T cell that prevents the development of oviduct dilation following C. muridarum genital infection. Phenotypic studies show that CD8⁺CXCR5⁺ cells express markers of T regulatory cells (FoxP3, CD25, and GITR) but do not express a necessary component of cytotoxic cells (perforin). Cxcr5⁻/⁻ mice have significantly lower numbers of CD8⁺ cells and lack the CD8⁺CXCR5⁺ p...